GWAS of Dental Caries Patterns in the Permanent Dentition

摘要: The importance of susceptibility genes in the risk for dental caries has been clearly established. While many candidate have proposed, to date, few them rigorously validated through observational and experimental studies. Moreover, most genetic epidemiological studies analyzed global phenotypes that ignore possibility may exert differential effects across tooth surfaces dentition. Therefore, we performed genome-wide association (GWAS) 5 novel (developed by clustering permanent dentition into categories based on co-occurrence caries) nominate new genes. GWAS was 920 self-reported white participants, aged 18 75 years, with genotype data 518,997 variants. We identified a significant between anterior mandibular teeth LYZL2 (p value = 9e-9), which codes bacteriolytic agent thought be involve...