Trifluoroethanol and liquid-assisted grinding method: a green catalytic access for multicomponent synthesis

作者: Trushant Lohar , Ananda Mane , Siddharth Kamat , Arjun Kumbhar , Rajashri Salunkhe

DOI: 10.1007/S11164-017-3206-Y

关键词:

摘要: An efficient and versatile mechanochemical route for the synthesis of chromene isoindolo[2,1-a]quinazoline scaffolds has been developed via a simple mortar pestle liquid-assisted grinding method using 2,2,2-trifluoroethanol (TFE) as an catalyst. The present protocol is very it offers reaction in mild condition, cleaner profiles, effortless work-up step with excellent purity, high yield desired products short time.

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