Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma.

摘要: Interleukin-10 (IL-10) is an acid-sensitive protein of 35 kD that has pleiotropic effects including inhibition cytotoxic T-cell response, induction major histocompatibility complex type II in B lymphocytes, B-cell growth and differentiation, autocrine factor activity monocytes. We others have shown IL-10 produced spontaneously by blood mononuclear cells from human immunodeficiency virus-seropositive patients. In attempt to ascertain the potential role acquired syndrome (AIDS)-related lymphoma, we evaluated expression both tumor-derived lines primary tumor cells. Expression (hIL-10) mRNA was detected four five cell examined. An antisense oligonucleotide inhibited production. The proliferation all a dose-dependent manner abrogated addition recombinant hIL-10 protein. No effect observed line not producing hIL-10. Evaluation patients with AIDS-lymphoma showed similar production response IL-10. These data suggest mechanism for AIDS-related lymphoma may be important its pathogenesis.