Abstract C32: Native American genetic ancestry is protective against prostate cancer in African Americans and European Americans

摘要: Prostate cancer (PCa) incidence and mortality varies by racial/ethnic groups in the U.S. African American (AA) men have a 60% higher twice rate of European America (EA) men, while Hispanic Americans Native lower rates than EA men. Several genetic admixture studies examined role west ancestry on prostate risk AA however influence PCa has not been explored. Here we evaluated relationship between individual proportions likelihood diagnosis aggressiveness. Methods: We recruited 40-79 year old who were undergoing biopsy or routine PSA screening at outpatient urology clinics Chicago, IL. Blood was drawn time enrollment for genotyping 105 informative markers. West African, European, estimated using Bayesian Markov Chain-Monte Carlo method implemented program STRUCTURE. Unconditional binary logistic regression models used to estimate odds ratios having high-risk relative controls, adjusting age family history PCa. Results: In AAs, NAA ranged from 0.4% 28.8%. Mean 4.6% cases, controls had mean 6.6%. 0.5% 17.4% EAs. 5.1% cases 6.8% controls. negatively associated with diagnosis. highest quartile significantly reduced compared lowest (OR 0.47, 95% C.I.: 0.29-0.77). Similarly, 0.36, 0.21-0.61). Additional adjustment body mass index, education, smoking, alcohol use, marital status did change results. also high EAs (P=0.04) trending same direction AAs significant. Conclusions: Our study reveals that is protective against EAs, identification inherited environmental factors are may improve prediction and/or help develop prevention strategies. Citation Format: Adam Murphy, Ken Batai, Ebony Shah, Rick A. Kittles. Americans. [abstract]. In: Proceedings Eighth AACR Conference The Science Health Disparities Racial/Ethnic Minorities Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr C32.