Amitriptyline and nortriptyline inhibit interleukin-1 release by rat mixed glial and microglial cell cultures.

摘要: Pro-inflammatory cytokines, such as interleukin (IL)-1 β and tumour necrosis factor (TNF)- α have been suggested to be involved in the pathophysiology of depression mechanism action antidepressant drugs. Until now effect antidepressants on cytokines has examined only plasma, blood mononuclear cells spleen, which reflect activity peripheral cytokine network. The aim this study was evaluate amitriptyline its metabolite nortriptyline release IL-1 TNF- by lipopolysaccharide (LPS)-activated rat mixed glial microglial cell cultures. LPS stimulated both cytokines. exposure culture led a decrease release. Moreover, reduced LPS-stimulated Although secretion drug did not affect mRNAs Our shown for first time that administered at concentrations may achieved plasma brain structures during treatment, inhibit obtained results support previous observations are able reduce pro-inflammatory suggest network central nortriptyline.