Human Genetic Susceptibility to Amebiasis
作者： Shannon N. Moonah , Nona M. Jiang , William A. Petri
DOI: 10.1007/978-4-431-55200-0_28
关键词:
摘要: One important unanswered question in amebic research is why only a proportion of individuals exposed to Entamoeba histolytica develop clinical disease. Variation host genetic makeup key explaining interindividual differences susceptibility amebiasis. In this chapter, we discuss the effects nonsynonymous polymorphism leptin receptor and HLA class II alleles mediating resistance prospective study on cohort preschool children living Dhaka, Bangladesh, with two copies ancestral Q223 allele were resistant Children mice at least one copy 223R mutation more susceptible colitis. DQB1*0601 heterozygous haplotype DQB1*0601/DRB1*1501 found be protective against human intestinal An understanding genes that underlie amebiasis could open new potential therapeutic prophylactic pathways management
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