Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice.

摘要: Human complement receptors type 1 (hCR1;CD35) and 2 (hCR2;CD21) are expressed on B lymphocytes at specific stages during differentiation activation. These play critical roles in the immune response to T-dependent Ags addition germinal center formation. Expression of both hCR2 hCR1 is decreased patients with systemic lupus erythematosus (SLE). We have studied expression mouse CR2 CR1 normal populations BALB/c mice. Our results demonstrate that these state closely parallels hCR2. During bone marrow development, first detected low B220/high IgM cells, demonstrating appear after central tolerance mechanisms completed. In splenic microenvironment highest levels receptor found marginal zone lymphocytes. Mouse also peritoneal B1a B1b cells IgA+ Peyer's patch cells. Activation under Th2 conditions a marked decrease expression. To determine whether patterns parallel those human disease, we MRL lpr/lpr (MRL/lpr) model SLE. Interestingly, an early progressive detectable before major clinical manifestations nephritis. hypothesize such as demonstrated by MRL/lpr mice plays important role pathogenesis murine perhaps