Platinum(II) O,S Complexes Inhibit the Aggregation of Amyloid Model Systems.
作者： Daniele Florio , Anna Maria Malfitano , Sarah Di Somma , Carolin Mügge , Wolfgang Weigand
DOI: 10.3390/IJMS20040829
关键词:
摘要: Platinum(II) complexes with different cinnamic acid derivatives as ligands were investigated for their ability to inhibit the aggregation process of amyloid systems derived from Aβ, Yeast Prion Protein Sup35p and C-terminal domain nucleophosmin 1. Thioflavin T binding assays circular dichroism data indicate that these compounds strongly peptides exhibiting IC50 values in micromolar range. MS analysis confirms formation adducts between Pt(II) are also able reduce cytotoxicity human SH-SY5Y neuroblastoma cells. Overall suggests bidentate based on β-hydroxy dithiocinnamic esters can be used develop platinum or platinoid anti-amyloid properties.
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