Nitric oxide scavenging by hemoglobin regulates hypoxic pulmonary vasoconstriction
作者： Steven Deem
DOI: 10.1016/J.FREERADBIOMED.2003.11.025
关键词:
摘要: Although the importance of red blood cells in augmenting hypoxic pulmonary vasoconstriction has been recognized for decades, only recently it become clear that this occurs primarily because inactivation nitric oxide (NO) by hemoglobin. This interaction between cells, NO, and circulation is critical understanding effects anemia polycythemia on flow distribution, gas exchange, global O2 delivery development hemoglobin-based oxygen carriers. review will discuss proposed mechanisms initiation regulation with an emphasis hemoglobin-NO interactions. In addition, how biologic (S-nitrosation) or pharmacologic (cross-linking) modification hemoglobin may affect circulatory-hemoglobin
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