作者: Steven C Hunt , Marta Gwinn , Ted D Adams
DOI: 10.1016/S0749-3797(02)00586-X
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摘要: Family history assessment can be used to combine population-wide health promotion and risk-reduction efforts with a high-risk, targeted approach help reduce the burden of cardiovascular disease (CVD). is an independent predictor CVD, upper portion family distribution explains larger fraction CVD in population than explained by extreme values other risk factors (e.g., blood pressure cholesterol). A positive captures underlying complexities gene–gene gene–environment interactions identifying families combinations factors, both measured unmeasured, that lead expression. useful tool for most prevalent cases disease-prevention efforts. also identifies relatively small subset at highest who may benefit from screening intensive intervention.