Marine Compounds and Cancer: Where Do We Stand?

摘要: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in therapy, there still an urgent need for new drugs oncology. Current development favors so called “targeted agents” or that target immune system, i.e., therapeutic antibodies enhance facilitate response against tumor cells (also referred to as “checkpoint inhibitors”). However, until recently, roughly 60% used hematology and oncology were originally derived from natural sources, one third top-selling agents are either derivatives [1]. There justified hope discovery anticancer marine environment. Historically, this habitat has proven be a rich source potent compounds such alkaloids, steroids, terpenes, macrolides, peptides, polyketides, others. Interestingly, treatment have had special relationship beginning. One first marine-derived compounds, discovered 1945 was later developed into clinically drug, spongothymidine [2–4], which lead compound cytarabine [5]. Until today, remains widely acute myeloid leukemia relapsed aggressive lymphomas. [...]