Diurnal salivary cortisol and nativity/duration of residence in Latinos: The Multi-Ethnic Study of Atherosclerosis.

摘要: Abstract Latino immigrants have lower prevalence of depression, obesity and cardiovascular disease than US-born Latinos when they are recently arrived in the US, but this health advantage erodes with increasing duration US residence. Cumulative exposure to psychosocial stress its physiological sequelae may mediate relationship between nativity residence poor health. We used data from cohort study participants ages 45–84 examine cross-sectional (n = 558) longitudinal (n = 248) associations features diurnal cortisol curve including: wake-up cortisol, awakening response (CAR, 30 min post-awakening), early decline (30 min 2 h post-awakening) late (2 h post-awakening bed time), wake-to-bed slope, area under (AUC). In analyses, had higher fewer 30 years full sample, over 5 CAR became flatter AUC larger. Over years, greater increases less pronounced flattening Immigrants or more also relative recent immigrants, a increase AUC. sum, we saw limited evidence that dysregulated recently-arrived time slower progression dysregulation.