Chapter 4. Cholecystokinin and Substance P in the Central Nervous System

摘要: Publisher Summary The two neuropeptides that have attracted most interest amongst pharmacologists are cholecystokinin (CCK) and substance P. reason for this in CCK is primarily because of the co-existence a CCK-like immunoreactivity with dopamine neurones mesolimbic dopaminergic neurones, perhaps providing clue to novel approaches therapy parkinson's disease schizophrenia which underactivity or hyperactivity, respectively, implicated. In case P, localization neuropeptide small diameter primary afferent sensory fibers suggests P other peptides may be responsible transmission “painful” information through spinal cord higher centers central nervous system (CNS), so development antagonists might provide new class nonopioid analgesic drugs. octaeptide major like peptide found CNS it belongs cerulein family peptides. ceruleins, tachykinins, amphibian skin carboxyterminal pentapeptide sequence CCK-8 identical gastrin both unusual being sulfated. similarities between led original scription brain as “gastrin,” confusion can resolved by sequencing ovine CCK-8. Development suitable radioimmunoassays improved immunocytochemical techniques localized immune reactivity particular cerebral cortex, basal ganglia hypothalamus, all mammalian species including human.