Rapid Induction of Specific Cytotoxic T Lymphocytes Against Melanoma-Associated Antigens by a Recombinant Vaccinia Virus Vector Expressing Multiple Immunodominant Epitopes and Costimulatory Molecules In Vivo
作者： Daniel Oertli , Walter R. Marti , Paul Zajac , Christoph Noppen , Thomas Kocher
DOI: 10.1089/10430340252809856
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摘要: A specific cellular immune response directed against a panel of three defined tumor-associated antigen (TAA) epitopes was induced in metastatic melanoma patients by prime-boost strategy taking advantage an innovative recombinant vaccinia virus as evaluated quantitative assessment cytotoxic T lymphocytes (CTLs) with corresponding specificity. The immunization protocol consisted the administration psoralen-UV-treated and replication-incompetent encoding immunodominant HLA-A*0201-restricted Melan-A27-35, gp100280-288, tyrosinase1-9 together two costimulatory molecules, B7.1 B7.2, context systemic granulocyte-macrophage colony-stimulating factor (GM-CSF) treatment. Boosts were subsequently applied synthetic nonapeptides GM-CSF. Specific CTL induction assessed tetramer staining precursor (CTLp) frequency evaluation. Within 12 days injection vector, cell r...
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