Do proinflammatory cytokines play a role in clozapine-associated glycometabolism disorders?

摘要: Clozapine (CLZ) is the most effective drug for treatment-resistant schizophrenia but associated with many side effects, including glycometabolism disorders. Immunological mechanisms may be involved in development of clozapine effects. Research relating immunomodulatory effects and its early markers to clinically relevant adverse events needed reduce harmful clozapine. This study aimed investigate role proinflammatory cytokines clozapine-associated We measured effect a range doses on glycometabolism-related parameters levels mice peripheral blood. also examined differences between these indicators blood clozapine-treated patients healthy controls. Furthermore, we detected expression pancreatic tissue. Following administration, glucagon significantly decreased mouse serum, cytokine IL-β markedly increased. reliably increased (IL-1β, IL-6, TNF-α) murine Compared controls, patients’ BMI, glucose, significantly. In patients, higher daily dosage was IL-1β significant positive correlation observed glucose IL-6 TNF-α. Findings from animal experiments clinical trials have shown clear evidence that has regulatory immune-related influences indicators.