α-Glucosidase inhibitors as potential broad based anti-viral agents

摘要: N-Linked oligosaccharides play many roles in the fate and functions of glycoproteins. One function is to assist folding proteins by mediating interactions lectin-like chaperone calnexin calreticulin with nascent These can be prevented inhibitors alpha-glucosidases this causes some misfolded retained within endoplasmic reticulum. In human immunodeficiency virus (HIV) hepatitis B (HBV) misfolding key viral envelope glycoproteins interferes life cycle. It has been demonstrated an animal model chronic HBV that glucosidase alter glycosylation have anti-viral activity. As mechanism action alpha-glucosidase induction or otherwise defective glycoproteins, such may useful therapeutics for viruses, especially those which bud from reticulum (where protein takes place). For example bovine diarrhea virus, a pestivirus akin C also extremely sensitive inhibition.