A neuronal aging pattern unique to humans and common chimpanzees

摘要: Lipofuscin pigment accumulation is among the most prominent markers of cellular aging in postmitotic cells. The formation lipofuscin related to oxidative enzymatic activity and free radical-induced lipid peroxidation. In various mammals such as rat, dog, macaque well cheirogaleid primates, large neurons, cerebellar Purkinje cells neocortical pyramidal cells, show heavy adulthood. contrast, a well-known yet poorly studied feature human brain that although marked neurons cerebral cortex, cortex-the cells-appear remain accumulation. It however, not known whether this characteristic shared with other primates or mammals. This study reports results from histological observation humans, non-human Procedures include histochemistry, immunocytochemistry, fluorescence microscopy. Abundant deposition was observed all species we examined except Homo sapiens (including Alzheimer's disease cases) Pan troglodytes. dentate nucleus. Our findings suggest when compared chimpanzees humans might share common pattern involves mechanisms for neuroprotection. important considering animal models aging.