C. elegans vulval development as a model system to study the cancer biology of EGFR signaling.
作者： Chieh Chang , Paul W. Sternberg
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摘要: Molecular genetic studies of C. elegans vulval development have helped to define an evolutionarily conserved signaling pathway from EGF-like ligand through EGF-receptor, Ras and MAP kinase the nucleus. Further identified novel positive regulators such as KSR-1 SUR-8/SOC-2 negative cbl/SLI-1. The many regulatory proteins might serve prevent inappropriate signaling, thus are analogous tumor suppressor genes.
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R.V. Aroian, G.M. Lesa, P.W. Sternberg, Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function. The EMBO Journal. ,vol. 13, pp. 360- 366 ,(1994) , 10.1002/J.1460-2075.1994.TB06269.X
Wuyi Meng, Sansana Sawasdikosol, Steven J. Burakoff, Michael J. Eck, Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase Nature. ,vol. 398, pp. 84- 90 ,(1999) , 10.1038/18050
Andrew Fire, SiQun Xu, Mary K. Montgomery, Steven A. Kostas, Samuel E. Driver, Craig C. Mello, Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature. ,vol. 391, pp. 806- 811 ,(1998) , 10.1038/35888
William Barry Wood, The Nematode Caenorhabditis elegans Cold Spring Harbor Laboratory. ,(1988)
Paul W. Sternberg, Helen M. Chamberlin, The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans Development. ,vol. 120, pp. 2713- 2721 ,(1994) , 10.1242/DEV.120.10.2713
S Brenner, THE GENETICS OF CAENORHABDITIS ELEGANS Genetics. ,vol. 77, pp. 71- 94 ,(1974) , 10.1093/GENETICS/77.1.71
Edwin L Ferguson, H Robert Horvitz, Identification and Characterization of 22 Genes That Affect the Vulval Cell Lineages of the Nematode CAENORHABDITIS ELEGANS Genetics. ,vol. 110, pp. 17- 72 ,(1985) , 10.1093/GENETICS/110.1.17
Kerry Kornfeld, Dennis B. Hom, H.Robert Horvitz, The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans Cell. ,vol. 83, pp. 903- 913 ,(1995) , 10.1016/0092-8674(95)90206-6
Kerry Kornfeld, Kun-Liang Guan, H Robert Horvitz, None, The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes & Development. ,vol. 9, pp. 756- 768 ,(1995) , 10.1101/GAD.9.6.756
Mark S. Boguski, Frank McCormick, Proteins regulating Ras and its relatives Nature. ,vol. 366, pp. 643- 654 ,(1993) , 10.1038/366643A0