Antiretroviral therapy in pregnant women with advanced HIV disease and pregnancy outcomes in Abidjan, Côte d'Ivoire.

摘要: BACKGROUND: Pregnancy outcomes in women receiving highly active antiretroviral treatment (HAART) Africa are not well described. METHODS: HIV-1-infected pregnant the ANRS Ditrame Plus and MTCT-Plus projects were included. Between March 2001 July 2003, when HAART was yet available, eligible for received a short-course regimen, zidovudine (ZDV) or (ZDV + lamivudine) single dose of nevirapine preventing mother-to-child transmission (PMTCT group). August 2003 2007, it (HAART The frequencies low birth weight (LBW) (<2500 g), stillbirth infant mortality reported. Risk factors associated with LBW investigated using logistic regression model. RESULTS: Of 326 HIV-infected women, 175 (median CD4 cell count 177 cells/microl) 151 182 cells/microl). At 12 months, three paediatric infections (2.3%) occurred group vs. 25 (16.1%) PMTCT (P < 0.001). rate 22.3% 12.4% = 0.02). In multivariable analysis (n 309), after adjustment on maternal count, WHO stage, age BMI, initiated before pregnancy [adjusted odds ratio (OR) 2.88, 95% confidence interval (CI) 1.10-7.51] during (adjusted OR 2.12, CI 1.15-4.65) BMI at delivery 2.43, 1.20-4.91) LBW. CONCLUSION: African advanced HIV disease substantially reduced transmission, but