Distribution of neural plasticity in cerebellum-dependent motor learning.

摘要: The cerebellum is essential for some forms of motor learning. Two examples that provide useful experimental models are modification the vestibulo-ocular reflex and classical conditioning nictitating membrane response (NMR) in rabbit. There has been considerable analysis these behavioral eyelid blink reflex, which similar several respects to NMR but with key differences its control circuitry. evidence consistent suggestion storage memories be found within associated brainstem presents many advantages as a model system characterize cellular molecular mechanisms underpinning And yet, localizing synaptic changes proven difficult. A major problem establish what extent neural distributed through cerebellar cortex, nuclei, nuclei. Inspired by recent theoretical work, here we review distribution plasticity across cortical nuclear (or vestibular system) levels different learning tasks may distinct. Our primary focus on blink, offer comparisons modifications reflex. We describe view satisfies empirical analysis.