Genomewide comparison of DNA sequences between humans and chimpanzees

摘要: A total of 8,859 DNA sequences encompassing ∼1.9 million base pairs the chimpanzee genome were sequenced and compared to corresponding human sequences. Although average sequence difference is low (1.24%), extent changes markedly different among sites types substitutions. Whereas ∼15% all CpG have experienced between humans chimpanzees, owing a 23-fold excess transitions 7-fold transversions, substitutions at other vary in frequency, 0.1% 0.5%. If nucleotide diversity common ancestral species chimpanzees assumed been about fourfold higher than contemporary humans, possible comparisons autosomes X Y chromosomes result estimates ratio male female mutation rates ∼3. Thus, relative time spent germlines may be major determinant overall accumulation However, since divergence differs significantly autosomes, additional unknown factors must also influence genome.