Improving head growth in preterm infants – a randomised controlled trial II: MRI and developmental outcomes in the first year
作者： M Tan , L Abernethy , R Cooke
关键词:
摘要: Background: Very preterm infants are at risk of poor growth and neurodevelopmental outcome. Illness difficulties overcoming the challenges feeding these often lead to undernutrition in first few weeks. Objective: To explore relationships between early nutrition, post-natal head growth, quantitative magnetic resonance imaging (MRI) developmental outcome year among born before 29 weeks9 gestation. Design: Infants gestation were randomised receive hyperalimented or standard regimen from birth 34 postmenstrual age (PMA). The primary was occipitofrontal circumference (OFC) 36 OFC. Quantitative MRI performed 40 PMA. Developmental assessment using Bayley Scales Infant Development II (BSID II) carried out 3 9 months post-term. Results: 109 survived end 65 underwent scan. 81 71 seen findings, mental development index (MDI) psychomotor (PDI) not statistically different two groups. Total brain volume (TBV) PMA, MDI PDI post-term correlated significantly with energy deficit 28 days Conclusions: Improving very may promote growth. have a role play predicting Post-natal PMA finding appear be closely related outcomes year. Trial registration number: ISRCTN 19509258
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