Prognostic significance of FOXP1 as an oncogene in hepatocellular carcinoma

摘要: Background Forkhead Box P1 (FOXP1) has been described as both a tumour suppressor candidate and potential oncogene. The aim of this study is to identify new prognostic biomarkers therapeutic target structures for the diagnosis treatment hepatocellular carcinoma (HCC). Methods expression FOXP1 mRNA in HCC was characterised using real-time PCR 20 pairs fresh frozen tissues corresponding non-cancerous tissues. protein confirmed immunohistochemistry on tissue microarray chip. Finally, correlated with conventional clinicopathological features patient outcome. Results cells much higher than normal hepatic (Z=2.315, p=0.021 χ 2 =28.071, 95% CI 0.233 0.480, p test analysis showed that high related large diameter (χ =6.210, p=0.013), serum α-fetoprotein levels =6.920, p=0.031) later stage grouping node metastasis classification =6.714, p=0.035). Kaplan–Meier survival Cox regression (HR=2.182, 1.146 4.154, p=0.018) regional lymph (HR=2.326, 1.037 5.217, p=0.041) were independent prognosis factors. Conclusions From investigation authors elucidated first time correlation correlates an aggressive malignant phenotype may constitute novel factor HCC. These results also support role oncogene