EMPHYSEMA AFTER LOW-LEVEL EXPOSURE TO NO2.

摘要: Rats were exposed to various levels of NO/sub 2/ for their life-span. At a concentration 100 ppM they began die within 24 h from acute pulmonary edema. 50 ppM, 6 9 rats died 48 68 days, 2 removed control environment. 25 sacrificed after 40 days appeared normal in weight but some had histopathologic lung changes (e.g., hyperplasia, hypertrophy). Ten 15 121 180 1 other causes 7 was allowed recover, 3 sacrificed. Low body noted. 12.5 8 survived. One with above pathology at 213 days. Body weights 20% less than normal. Increased respiratory rate 60 per min as opposed Emphysema occurred terms voluminous lungs no inflammation. Hyperplasia, accumulation mucus and macrophages may obstruct terminal bronchioles.