MiR-486-5p inhibits the hyperproliferation and production of collagen in hypertrophic scar fibroblasts via IGF1/PI3K/AKT pathway.

作者: Yifeng Xiao

DOI: 10.1080/09546634.2020.1728210

关键词:

摘要: … the expression of miR-486-5p in HS and hypertrophic scar fibroblasts (HSFBs). Viability, migration, invasion … The activation of PI3K/AKT pathway was also analyzed by Western blot. …

参考文章(50)
Brian Berman, Andrea Maderal, Brian Raphael, Keloids and Hypertrophic Scars Dermatologic Surgery. ,vol. 43, pp. S3- S18 ,(2017) , 10.1097/DSS.0000000000000819
Itay Bentov, Haim Werner, Insulin-like Growth Factor-1 Handbook of Biologically Active Peptides (Second Edition). pp. 1627- 1632 ,(2013) , 10.1016/B978-0-12-385095-9.00222-0
Celeste C Finnerty, Marc G Jeschke, Ludwik K Branski, Juan P Barret, Peter Dziewulski, David N Herndon, Hypertrophic scarring: the greatest unmet challenge after burn injury. The Lancet. ,vol. 388, pp. 1427- 1436 ,(2016) , 10.1016/S0140-6736(16)31406-4
Xiao-Ming Meng, Shuang Wang, Xiao-Ru Huang, Chen Yang, Jun Xiao, Yang Zhang, Ka-Fai To, David J Nikolic-Paterson, Hui-Yao Lan, None, Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis. Cell Death and Disease. ,vol. 7, ,(2016) , 10.1038/CDDIS.2016.402
S. Hessam, M. Sand, M. Skrygan, T. Gambichler, F. G. Bechara, Expression of miRNA-155, miRNA-223, miRNA-31, miRNA-21, miRNA-125b, and miRNA-146a in the Inflammatory Pathway of Hidradenitis Suppurativa Inflammation. ,vol. 40, pp. 464- 472 ,(2017) , 10.1007/S10753-016-0492-2
Ling Chen, Jingyun Li, Qian Li, Hui Yan, Bei Zhou, Yanli Gao, Jun Li, Non-Coding RNAs: The New Insight on Hypertrophic Scar Journal of Cellular Biochemistry. ,vol. 118, pp. 1965- 1968 ,(2017) , 10.1002/JCB.25873
Yue Guo, Chen-Yi Tang, Xiao-Fei Man, Hao-Neng Tang, Jun Tang, Ci-La Zhou, Shu-Wen Tan, Min Wang, Yun-Zhi Feng, Hou-De Zhou, Insulin-like growth factor-1 promotes osteogenic differentiation and collagen I alpha 2 synthesis via induction of mRNA-binding protein LARP6 expression. Development Growth & Differentiation. ,vol. 59, pp. 94- 103 ,(2017) , 10.1111/DGD.12342
Jie Zhang, Guangpu Fan, Hui Zhao, Zhiwei Wang, Fei Li, Peide Zhang, Jing Zhang, Xu Wang, Wei Wang, Targeted inhibition of Focal Adhesion Kinase Attenuates Cardiac Fibrosis and Preserves Heart Function in Adverse Cardiac Remodeling Scientific Reports. ,vol. 7, pp. 43146- ,(2017) , 10.1038/SREP43146
Haiyang Wang, Chongyang Tang, Meng Na, Wei Ma, Zhenfeng Jiang, Yifei Gu, Guizhen Ma, Haitao Ge, Hong Shen, Zhiguo Lin, miR-422a Inhibits Glioma Proliferation and Invasion by Targeting IGF1 and IGF1R. Oncology Research. ,vol. 25, pp. 187- 194 ,(2017) , 10.3727/096504016X14732772150389
Zhenjie Li, Runxia Jiang, Qingcai Yue, Haiying Peng, MicroRNA-29 regulates myocardial microvascular endothelial cells proliferation and migration in association with IGF1 in type 2 diabetes Biochemical and Biophysical Research Communications. ,vol. 487, pp. 15- 21 ,(2017) , 10.1016/J.BBRC.2017.03.055