作者: J.A. Light , D.Y. Barhyte , L. Lahman
DOI: 10.1016/J.TRANSPROCEED.2004.11.025
关键词:
摘要: Background. The outcome differences between ethnic groups after kidney transplantation have led to the characterization of African Americans (AA) as having high immune risk. Several multicenter clinical trials reported better outcomes when AA receive higher doses immunosuppression (I/S), suggesting pharmacokinetic (PK) and pharmacodynamic (PD) differences. However, donor source has not been cited an risk factor for outcome. Methods. Patient graft survival rates 469 were compared with 308 non-African (nAA) who received transplants January 1, 1995 December 31, 2002, followed-up through 2003. Gender, age, I/S protocol different groups. Based on outcomes, open laparoscopic combined analysis. Deceased kidneys comprised 49% but only 32% nAA (P <.000). Kaplan-Meier statistics used both patient survival. Results. at 3, 5, 7 years statistically living (log rank statistic, 1 df, P =.56) versus deceased =.15). Kidney similar =.493), significantly =.026). Conclusions. majority donation occurred ethnically donor-recipient pairs, whereas donors tended be nAA. difference demonstrated by suggests that antigens may more dissimilar or uniquely