Differential expression of homing-associated adhesion molecules by T cell subsets in man.

摘要: The ability of lymphocyte populations to recognize and bind high endothelial venules during homing into lymphoid tissues sites chronic inflammation is critically dependent on their expression certain homing-associated adhesion molecules known as receptors (HR). In animal models, populations, particularly subsets memory or previously activated lymphocytes, demonstrate tissue-selective behavior, it has been hypothesized that differential HR accounts for this selective migration. study, we analyzed human HR--the Dreg 56/Leu 8-defined peripheral lymph node (PLN) (also LECAM-1), H-CAM (CD44), alpha 4-integrins (CD49d; VLA-4)--among thymocytes blood T cells identify with potential. the thymus, these three classes are differentially regulated relative phenotypically defined maturational stages, but all expressed mature, surface CD3high subset. blood, virgin (LFA-3/CD58low) show uniform PLN HR, relatively low 4-integrin, lack markers tissue association--the mucosal cutaneous associated Ag (MLA CLA Ags) by mAb Ber ACT8 HECA-452, respectively. contrast, circulating (LFA-3/CD58high) bimodal respect expression, contain essentially MLA Ag-bearing cells. skin-associated cell subset (CLA Ag+; 10 15% total cells) predominantly HR+, shows levels both 4- beta 1-integrin chains. distinct mucosa-associated 1 3% HR-; 4high, 1low. These findings indicate independent regulation among memory/previously cells, suggest patterns contribute to, perhaps determine, distribution subsets.