Altering protein turnover in tumor cells: new opportunities for anti-cancer therapies.
作者： Francesca Demarchi , Claudio Brancolini
DOI: 10.1016/J.DRUP.2005.12.001
关键词:
摘要: The promising effects of the proteasome inhibitor bortezomib (Velcade, PS-341) in treatment certain types cancer have fired up interest on this multicatalytic proteolytic machinery. A number recent reviews thoroughly describe various aspects ubiquitin-proteasome system and its importance control cell growth tumorigenesis. Here, we will focus data unveiling a link between some elements apoptotic machinery including Bcl-2 members, caspases, IAPs IAP antagonists. Perturbing their turnover significantly contributes to response anti-neoplastic activity inhibitors.
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