Acetic acid-promoted eco-friendly one-pot pseudo six-component synthesis of bis-spiro-substituted piperidines
作者： Mir Rasul Mousavi , Hadigheh Gharari , Malek Taher Maghsoodlou , Nourallah Hazeri
DOI: 10.1007/S11164-015-2250-8
关键词:
摘要: A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of 15-(aryl)-3,3,11,11-tetramethyl-15-azadispiro[5.1.5.3]hexadecane-1,5,9,13-tetrone by pseudo six-component condensation between formaldehyde, dimedone, aromatic amine using the dual role acetic acid as solvent catalyst at room temperature. Ambient conditions avoidance conventional work-up well purification procedure qualify this economical cost-effective “green synthesis”. High efficiency, inexpensiveness, non-toxicity are interesting features methodology, which make it eco-friendly highly attractive. One important advantages methodology compared to previous methods is that electron-withdrawing substituent anilines also give desired product was not possible methodologies Kozlov Mukhopadhyay.
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