Endothelial nitric oxide synthase gene haplotypes affect nitrite levels in black subjects.
作者： I F Metzger , M H Ishizawa , F Rios-Santos , W A Carvalho , J E Tanus-Santos
DOI: 10.1038/TPJ.2010.52
关键词:
摘要: Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been associated with variations (NO) formation and response to drugs white subjects. We examined whether genetic polymorphisms (T-786C, b/a intron 4 Glu298Asp) haplotypes of eNOS affect NO 179 healthy black To assess formation, we measured concentrations nitrite plasma, red blood cells whole blood. Although found no effects individual on that ‘C-4b-Glu’ haplotype is significantly more common subjects low circulating plasma compared high (both P<0.0007). These findings reproduce previous are consistent idea defining markers important than ethnic classification, at least terms formation.
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