Model-based study of the human cupular time constant.

摘要: The time constant of the angular vestibulo-ocular reflex (aVOR), measured from response to steps rotation about a yaw axis, has frequently been estimated as single exponential. However, slow phase velocity envelope during per- or post-rotatory nystagmus is more accurately represented by two exponential modes. One represents activity in vestibular nerve induced deflection cupula, other activation that input canals produces central storage integrator. sum cupula and integrator responses describes overall eye can be approximated double Frequently, there plateau initial portion response, but this may masked habituation, making contribution unobservable impossible estimate. Using model-based technique analyze with clear plateau, we peripheral constants fits velocity. Cupular were varied 1 10 s identify values gave optimal data according Chi-square criterion. mean cupular for human subjects was 4.2 +/- 0.6 s. Fits also good between 3.5 7 s, not 3 7.5 fit where no plateau. In 8 monkeys, 3.9 0.5 which agreed those derived nerve. There difference monkey these estimates. It likely similar shorter than previously thought.