The Effect of Nitroglycerin on the Systemic and Coronary Circulation in Man and Dogs
作者： L. BERNSTEIN , G. C. FRIESINGER , P. R. LICHTLEN , R. S. ROSS
关键词:
摘要: The pharmacodynamics of nitroglycerin have been studied in dogs and man. In dogs, intravenous (TNG) caused a decrease left ventricular work, myocardial blood flow (MFB), oxygen consumption, no significant change coronary vascular resistance. Intracoronary artery TNG an immediate increase MBF resistance that persisted until arterial pressure fell. In man, sublingual (0.4 mg.) MBF, patients with without arteriographically proven disease. The injection doses 0.1 to 0.2 mg. directly into the man hypothesis proposed for mechanism action relief angina pectoris is first, due its effect on circulation, and, secondly, cardiac work systemic circulation.
sci-hub.se 参考文章(17)
W.M. Fam, P. Sekelj, M. McGregor, 19. Contrasting effects of nitroglycerin and dipyridamole on myocardial oxygen tension in dogs with areas of chronic myocardial ischemia American Journal of Cardiology. ,vol. 15, pp. 129- 130 ,(1965) , 10.1016/0002-9149(65)90629-6
T. Lauder Brunton, ON THE USE OF NITRITE OF AMYL IN ANGINA PECTORIS. The Lancet. ,vol. 90, pp. 97- 98 ,(1867) , 10.1016/S0140-6736(02)51392-1
RAMON V. CANENT, MADISON S. SPACH, W. GLENN YOUNG, Cardiopulmonary Dynamics in Patients with Anastomosis of the Superior Vena Cava to the Right Pulmonary Artery Circulation. ,vol. 30, pp. 47- 54 ,(1964) , 10.1161/01.CIR.30.1.47
Carl R. Honig, Stephen Marsh Tenney, Paul V. Gabel, The mechanism of cardiovascular action of nitroglycerine The American Journal of Medicine. ,vol. 29, pp. 910- 923 ,(1960) , 10.1016/0002-9343(60)90073-5
J.Stauffer Lehman, Bernard L. Segal, William Likoff, Hratch Kasparian, Evaluation of “coronary vasodilators” by coronary arteriography The American Journal of Cardiology. ,vol. 13, pp. 7- 9 ,(1964) , 10.1016/0002-9149(64)90215-2
R. Wégria, Hiram E. Essex, J.F. Herrick, Frank C. Mann, The simultaneous action of certain drugs on the blood pressure and on the flow in the right and left coronary arteries American Heart Journal. ,vol. 20, pp. 557- 572 ,(1940) , 10.1016/S0002-8703(40)90934-6
Norman H. Boyer, Harold D. Green, The effects of nitrites and xanthines on coronary inflow and blood pressure in anesthetized dogs American Heart Journal. ,vol. 21, pp. 199- 214 ,(1941) , 10.1016/S0002-8703(41)90968-7
R.J. Bing, M.M. Hammond, J.C. Handelsman, S.R. Powers, F.C. Spencer, J.E. Eckenhoff, W.T. Goodale, J.H. Hafkenschiel, S.S. Kety, The measurement of coronary blood flow, oxygen consumption, and efficiency of the left ventricle in man American Heart Journal. ,vol. 38, pp. 1- 24 ,(1949) , 10.1016/0002-8703(49)90788-7
RICHARD GORLIN, NORMAN BRACHFELD, COLIN MACLEOD, PIERRE BOPP, Effect of Nitroglycerin on the Coronary Circulation in Patients with Coronary Artery Disease or Increased Left Ventricular Work Circulation. ,vol. 19, pp. 705- 718 ,(1959) , 10.1161/01.CIR.19.5.705
Germano V. Marchetti, Licia Merlo, Roberta M. Antognetti, The effects of nitroglycerin on the coronary blood flow and oxygen consumption of the myocardium in anesthetized dogs The American Journal of Cardiology. ,vol. 13, pp. 51- 57 ,(1964) , 10.1016/0002-9149(64)90222-X