Mitrecin a polypeptide with antimicrobial activity

作者: Michael Heath Farris

DOI:

关键词:

摘要: The present invention provides a Mitrecin A polypeptide useful in prevention and treatment of one or more bacteria. Also provided is method to kill prevent growth bacteria comprising contacting the with polypeptide. target can be selected from group consisting Gram-positive bacterium, Gram-negative both. In embodiment, drawn polynucleotide encoding polypeptide, vector polynucleotide, host cell composition vector, cell.

参考文章(17)
M. Heath Farris, Julie B. Olson, Perry F Churchill, A novel bacteriocin from a new streptomyces species ,(2008)
S. Karlin, S. F. Altschul, Applications and statistics for multiple high-scoring segments in molecular sequences. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 5873- 5877 ,(1993) , 10.1073/PNAS.90.12.5873
Steven A. Muhle, James P. Tam, Design of Gram-negative selective antimicrobial peptides. Biochemistry. ,vol. 40, pp. 5777- 5785 ,(2001) , 10.1021/BI0100384
Nadezhda V. Kulagina, Michael E. Lassman, Frances S. Ligler, Chris Rowe Taitt, Antimicrobial peptides for detection of bacteria in biosensor assays. Analytical Chemistry. ,vol. 77, pp. 6504- 6508 ,(2005) , 10.1021/AC050639R
Zhang Wang, Daniel E Kadouri, Martin Wu, None, Genomic insights into an obligate epibiotic bacterial predator: Micavibrio aeruginosavorus ARL-13 BMC Genomics. ,vol. 12, pp. 453- 453 ,(2011) , 10.1186/1471-2164-12-453
A-M Darquet, B Cameron, P Wils, D Scherman, J Crouzet, A new DNA vehicle for nonviral gene delivery: supercoiled minicircle. Gene Therapy. ,vol. 4, pp. 1341- 1349 ,(1997) , 10.1038/SJ.GT.3300540
Runqi Zhou, Shigen Chen, Paul Recsei, A dye release assay for determination of lysostaphin activity. Analytical Biochemistry. ,vol. 171, pp. 141- 144 ,(1988) , 10.1016/0003-2697(88)90134-0
Byung-Joon Kim, Jie Zhou, Bronwen Martin, Olga D. Carlson, Stuart Maudsley, Nigel H. Greig, Mark P. Mattson, Ellen E. Ladenheim, Jay Wustner, Andrew Turner, Homayoun Sadeghi, Josephine M. Egan, Transferrin Fusion Technology: A Novel Approach to Prolonging Biological Half-Life of Insulinotropic Peptides Journal of Pharmacology and Experimental Therapeutics. ,vol. 334, pp. 682- 692 ,(2010) , 10.1124/JPET.110.166470