Protecting the ischemic spinal cord during aortic clamping. The influence of anesthetics and hypothermia.

摘要: Infrarenal circumaortic occlusion devices were operatively placed in 74 New Zealand white rabbits. Two days after operation the animals randomly assigned to one of seven treatment groups: I, control, n = 23; II, halothane, 8; III, thiopental, 12; IV, ketamine (30 mg/kg intravenously), 6; V, halothane+hypothermia, VI, thiopental+hypothermia, VII, ketamine+hypothermia, 5. In each group, infrarenal aorta was occluded for 21 minutes. Final neurologic recovery restitution blood flow graded as acute paraplegia, delayed paraplegia (neurologic deficit developing initial recovery), or normal. Halothane alone no benefit. Hypothermia with any anesthetic completely protective and reduced deficits 0% compared 91% controls (p less than 0.05). Thiopental 17% (as 61% controls) increased from 30% 75% 50%, respectively 0.05 p 0.10 ketamine). The authors interpret increase decrease being result partial spinal cord protection. These findings document that this model ischemia is sufficiently sensitive identify interventional treatments protect ischemic cord.