Family-Based SNP Association Study on 8q24 in Bipolar Disorder

摘要: Previous linkage studies have identified chromosome 8q24 as a promising positional candidate region to search for bipolar disorder (BP) susceptibility genes. We, therefore, sought identify BP genes on using family-based association study of dense panel SNPs selected tag the known common variation across interest. A total 1,458 16 Mb were examined in 3,512 subjects, 1,954 whom affected with BP, from 737 multiplex families. Single-locus tests carried out FBAT and Geno-PDT, multi-locus test HBAT Geno-PDT. None associated single-locus at level that exceeded our threshold study-wide significance (P < 3.00 × 10−5). However, there was consistent evidence suggestive (P < 7.00 × 10−4) both single locus associations ADCY8, ST3GAL1, NSE2. Multi-locus analyses suggested joint effects between ADCY8 ST3GAL1 (P = 3.00 × 10−4), least one copy “high risk” allele required jointly dominant–dominant model action. These findings warrant further investigation order confirm observed their functional susceptibility. © 2007 Wiley-Liss, Inc.