CluStrat: A Structure Informed Clustering Strategy for Population Stratification
作者： Aritra Bose , Myson C. Burch , Agniva Chowdhury , Peristera Paschou , Petros Drineas
DOI: 10.1007/978-3-030-45257-5_19
关键词:
摘要: Genome-wide association studies (GWAS) have been extensively used to estimate the signed effects of trait-associated alleles. One key challenges in GWAS are confounding factors, such as population stratification, which can lead spurious genotype-trait associations. Recent independent [1, 8, 10] failed replicate strong evidence previously reported signals directional selection on height Europeans UK Biobank cohort, and attributed loss signal cryptic relatedness populations.
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