Expression of L-selectin on Th1 cells is regulated by IL-12.

摘要: L-selectin has become established as a key molecule in the recirculation of naive T cells from blood to peripheral lymph nodes, yet little is known about its role migration effector or memory cells. While differentiating CD4+ into Th1 and Th2 subsets vitro, it was noted that levels were maintained on subset The expression appeared be dependent presence IL-12. cells, differentiated absence IL-12, failed maintain expression. Coculture with IL-18, IL-4, TNF-α, IFN-α, -β, -γ demonstrated dependence IL-12 alone for In addition, inclusion heat-killed Listeria monocytogenes cultures also all cultures, maintenance cell surface could blocked by anti-IL-12 Abs. Analysis mRNA showed cytokine appears exert effect at transcriptional level. Given played differentiation subset, observation can regulate implications both through lymphatic system sites inflammation.