Thermo-activatable PNIPAM-functionalized lanthanide-doped upconversion luminescence nanocomposites used for in vitro imaging
作者： Po Li , Li Liu , Jing Zhou , Li Zhao , Haiming Fan
DOI: 10.1039/C7RA10859A
关键词:
摘要: Stimuli-responsive nanocomposite has a great potential application for cell imaging, drug delivery, and improving therapeutic effect. Rare-earth upconversion nanoparticles (UCNPs) have exhibited an excellent properties as promising biological luminescent labels fluorescence imaging. In this work, we prepared β-NaLuF4:Yb3+,Er3+ UCNPs coated with thermo-responsive copolymer poly(N-isopropyl acrylamide-co-acrylic acid) (P(NIPAM-co-AA)) by using ligand exchange strategy to obtain novel UCNP@P(NIPAM-co-AA). The acrylic acid moieties of P(NIPAM-co-AA) coordinate the surfaces UCNPs, PNIPAM can induce dispersion or aggregation in aqueous solution below above lower critical temperature (LCST) PNIPAM. UCNP@P(NIPAM-co-AA) weak luminescence(UCL) intensity LCST but 80-fold enhanced UCL at 31 °C their only 1 transition range. also shows remarkable reversible property low cytotoxicity. For vitro 13-fold signal-to-noise ratio be obtained thermo-activatable which implies intelligent biomedical agent.
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sci-hub.se 参考文章(26)
Daqin Chen, Lu Liu, Ping Huang, Mingye Ding, Jiasong Zhong, Zhenguo Ji, Nd(3+)-Sensitized Ho(3+) Single-Band Red Upconversion Luminescence in Core-Shell Nanoarchitecture. Journal of Physical Chemistry Letters. ,vol. 6, pp. 2833- 2840 ,(2015) , 10.1021/ACS.JPCLETT.5B01180
Daqin Chen, Ping Huang, Highly intense upconversion luminescence in Yb/Er:NaGdF4@NaYF4 core-shell nanocrystals with complete shell enclosure of the core Dalton Transactions. ,vol. 43, pp. 11299- 11304 ,(2014) , 10.1039/C4DT01237B
Masayuki Yamato, Yoshikatsu Akiyama, Jun Kobayashi, Joseph Yang, Akihiko Kikuchi, Teruo Okano, Temperature-responsive cell culture surfaces for regenerative medicine with cell sheet engineering Progress in Polymer Science. ,vol. 32, pp. 1123- 1133 ,(2007) , 10.1016/J.PROGPOLYMSCI.2007.06.002
Kazuo Suwa, Keitaro Morishita, Akio Kishida, Mitsuru Akashi, Synthesis and functionalities of poly(N-vinylalkylamide). V. Control of a lower critical solution temperature of poly(N-vinylalkylamide) Journal of Polymer Science Part A. ,vol. 35, pp. 3087- 3094 ,(1997) , 10.1002/(SICI)1099-0518(19971115)35:15<3087::AID-POLA1>3.0.CO;2-U
Songjun Zeng, Haibo Wang, Wei Lu, Zhigao Yi, Ling Rao, Hongrong Liu, Jianhua Hao, Dual-modal upconversion fluorescent/X-ray imaging using ligand-free hexagonal phase NaLuF4:Gd/Yb/Er nanorods for blood vessel visualization. Biomaterials. ,vol. 35, pp. 2934- 2941 ,(2014) , 10.1016/J.BIOMATERIALS.2013.11.082
Anna Gnach, Artur Bednarkiewicz, Lanthanide-doped up-converting nanoparticles: Merits and challenges Nano Today. ,vol. 7, pp. 532- 563 ,(2012) , 10.1016/J.NANTOD.2012.10.006
Zhengquan Li, Yong Zhang, Shan Jiang, Multicolor Core/Shell‐Structured Upconversion Fluorescent Nanoparticles Advanced Materials. ,vol. 20, pp. 4765- 4769 ,(2008) , 10.1002/ADMA.200801056
Lingzhi Zhao, Juanjuan Peng, Qi Huang, Chunyan Li, Min Chen, Yun Sun, Qiuning Lin, Linyong Zhu, Fuyou Li, Near‐Infrared Photoregulated Drug Release in Living Tumor Tissue via Yolk‐Shell Upconversion Nanocages Advanced Functional Materials. ,vol. 24, pp. 363- 371 ,(2014) , 10.1002/ADFM.201302133
Feng Wang, Yu Han, Chin Seong Lim, Yunhao Lu, Juan Wang, Jun Xu, Hongyu Chen, Chun Zhang, Minghui Hong, Xiaogang Liu, Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping Nature. ,vol. 463, pp. 1061- 1065 ,(2010) , 10.1038/NATURE08777
Liang Cheng, Chao Wang, Zhuang Liu, Upconversion nanoparticles and their composite nanostructures for biomedical imaging and cancer therapy Nanoscale. ,vol. 5, pp. 23- 37 ,(2013) , 10.1039/C2NR32311G