作者: Sven Maier , Ulrich Goebel , Sonja Krause , Christoph Benk , Martin A. Schick
DOI: 10.1371/JOURNAL.PONE.0205410
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摘要: Evoked potential monitoring has evolved as an essential tool not only for elaborate neurological diagnostics, but also general clinical practice. Moreover, it is increasingly used to guide surgical procedures and prognosticate outcome in the critical care unit, e.g. after cardiac arrest. Experimental animal models aim simulate a human-like scenario deduct relevant information patient treatment test novel therapeutic opportunities. Porcine are particularly ideal due comparable cardiovascular system size. However, certain anatomic disparities have be taken into consideration when evoked models. We describe non-invasive reproducible set-up useful different modalities porcine further illustrate hints overcome multi-faceted problems commonly occurring while using this sophisticated technique. Our descriptions can answer plethora of experimental questions, help facilitate innovation.