Taspine derivative 12k suppressed A549 cell migration through the Wnt/β-catenin and EphrinB2 signaling pathway.
作者： Bingling Dai , Yujiao Ma , Tianfeng Yang , Wenjie Wang , Yanmin Zhang
DOI: 10.1016/J.BIOPHA.2016.12.077
关键词:
摘要: Abstract 12k, a taspine derivative, has been demonstrated to have the potent anti-tumor activity in lung cancer and colorectal cancer. The study aims further explore underlying mechanisms of 12k on A549 cell migration vitro . Our data that negatively regulated Wnt signaling pathway by suppressing phosphorylation LRP5/6, inhibiting expression nuclear translocation β-catenin. was shown downregulate MMP3 MMP7 which β-catenin interacts with TCF/LEF nucleus, effectively impaired related protein MMP2 MMP9 cells. In addition, repressed EphrinB2 its PDZ protein, impairing VEGFR2 VEGFR3 cells, as well inhibited downstream included PI3 K/AKT/mTOR ERK/MAPK pathways. Taken together, our findings revealed suppressed cells through Wnt/β-catenin pathway.
sci-hub.se 参考文章(31)
E. Pennisi, CELL BIOLOGY:How a Growth Control Path Takes a Wrong Turn to Cancer Science. ,vol. 281, pp. 1438- 1441 ,(1998) , 10.1126/SCIENCE.281.5382.1438
Ombretta Salvucci, Giovanna Tosato, Essential Roles of EphB Receptors and EphrinB Ligands in Endothelial Cell Function and Angiogenesis Advances in Cancer Research. ,vol. 114, pp. 21- 57 ,(2012) , 10.1016/B978-0-12-386503-8.00002-8
Elena B. Pasquale, Eph receptor signalling casts a wide net on cell behaviour Nature Reviews Molecular Cell Biology. ,vol. 6, pp. 462- 475 ,(2005) , 10.1038/NRM1662
Charles E. Dann, Jen-Chih Hsieh, Amir Rattner, Divya Sharma, Jeremy Nathans, Daniel J. Leahy, Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains Nature. ,vol. 412, pp. 86- 90 ,(2001) , 10.1038/35083601
P. J. Morin, Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. ,vol. 275, pp. 1787- 1790 ,(1997) , 10.1126/SCIENCE.275.5307.1787
Ombretta Salvucci, Hidetaka Ohnuki, Dragan Maric, Xu Hou, Xuri Li, Sung Ok Yoon, Marta Segarra, Charles G. Eberhart, Amparo Acker-Palmer, Giovanna Tosato, EphrinB2 controls vessel pruning through STAT1-JNK3 signalling Nature Communications. ,vol. 6, pp. 6576- 6576 ,(2015) , 10.1038/NCOMMS7576
Bingling Dai, Wenjie Wang, Rui Liu, Hongying Wang, Yanmin Zhang, Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma Biomedicine & Pharmacotherapy. ,vol. 70, pp. 227- 233 ,(2015) , 10.1016/J.BIOPHA.2015.01.024
Yingdi Wang, Masanori Nakayama, Mara E. Pitulescu, Tim S. Schmidt, Magdalena L. Bochenek, Akira Sakakibara, Susanne Adams, Alice Davy, Urban Deutsch, Urs Lüthi, Alcide Barberis, Laura E. Benjamin, Taija Mäkinen, Catherine D. Nobes, Ralf H. Adams, Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis Nature. ,vol. 465, pp. 483- 486 ,(2010) , 10.1038/NATURE09002
Suphansa Sawamiphak, Sascha Seidel, Clara L. Essmann, George A. Wilkinson, Mara E. Pitulescu, Till Acker, Amparo Acker-Palmer, Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis Nature. ,vol. 465, pp. 487- 491 ,(2010) , 10.1038/NATURE08995
Elena B. Pasquale, Eph-ephrin bidirectional signaling in physiology and disease. Cell. ,vol. 133, pp. 38- 52 ,(2008) , 10.1016/J.CELL.2008.03.011