Anti-Inflammatory and Free Radial Scavenging Activities of the Constituents Isolated from Machilus zuihoensis
作者： Yi-Wen Mao , Hsiang-Wen Tseng , Wen-Li Liang , Ih-Sheng Chen , Shui-Tein Chen
DOI: 10.3390/MOLECULES16119451
关键词:
摘要: A new biflavonol glycoside, quercetin-3-O-β-D-glucopyranoside-(3'→O-3''')-quercetin-3-O-β-D-galactopyranoside (9), together with eight known compounds was isolated for the first time from leaves of Machilus zuihoensis Hayata (Lauraceae). The structure compound 9 elucidated by various types spectroscopic data analysis. Analysis biological activity assay found that showed significant superoxide anion scavenging (IC₅₀ is 30.4 μM) and markedly suppressed LPS-induced high mobility group box 1 (HMGB-1) protein secretion in RAW264.7 cells. In addition, HMGB-1 also inhibited quercitrin (3), ethyl caffeate (6), 3-O-caffeoylquinate (7) treatment. LPS-stimulated inducible nitric oxide synthase (iNOS) activation analysis, two compounds, quercetin (1) were to suppress (NO) production value, 27.6 42.9 μM, respectively) Additionally, it determined (6) down-regulated mRNA expressions iNOS, IL-1β, IL-10 LPS-treatment cells via a NF-kB pathway. These results suggested other constituents M. have potential anti-inflammatory effects. may be useful treating inflammatory diseases.
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Ju-Hyun Kim, Seon-Ju Kim, Im-Soon Lee, Myung-Shik Lee, Satoshi Uematsu, Shizuo Akira, Kwon Ik Oh, None, Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN-β Signaling Pathway Journal of Immunology. ,vol. 182, pp. 2458- 2466 ,(2009) , 10.4049/JIMMUNOL.0801364
Xiangdong Zhu, Xujun Dong, Yifeng Wang, Peng Ju, Shide Luo, Phenolic compounds from Viburnum cylindricum Helvetica Chimica Acta. ,vol. 88, pp. 339- 342 ,(2005) , 10.1002/HLCA.200590017
T. M Wright, Cytokines in acute and chronic inflammation Frontiers in Bioscience. ,vol. 2, pp. d12- 26 ,(1997) , 10.2741/A171
Rao Manjeet K, B Ghosh, Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-α production in murine macrophages International Journal of Immunopharmacology. ,vol. 21, pp. 435- 443 ,(1999) , 10.1016/S0192-0561(99)00024-7
Talat Roome, Ahsana Dar, Shamsher Ali, Sabira Naqvi, Muhammad Iqbal Choudhary, A study on antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective actions of Aegiceras corniculatum (stem) extracts Journal of Ethnopharmacology. ,vol. 118, pp. 514- 521 ,(2008) , 10.1016/J.JEP.2008.05.021
Irfan Rahman, Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets. Current Drug Targets - Inflammation & Allergy. ,vol. 1, pp. 291- 315 ,(2002) , 10.2174/1568010023344607
L. Ulloa, M. Ochani, H. Yang, M. Tanovic, D. Halperin, R. Yang, C. J. Czura, M. P. Fink, K. J. Tracey, Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 12351- 12356 ,(2002) , 10.1073/PNAS.192222999
Jun-Yan Tao, Lei Zhao, Zhi-Jun Huang, Xiao-Yu Zhang, Shu-Ling Zhang, Qiong-Guang Zhang, Fei-Xiao, Bao-Hui Zhang, Qi-Lin Feng, Guo-Hua Zheng, Anti-inflammatory effects of ethanol extract from Kummerowia striata (Thunb.) Schindl on lps-stimulated RAW 264.7 cell. Inflammation. ,vol. 31, pp. 154- 166 ,(2008) , 10.1007/S10753-008-9061-7
Tahira Farooqui, Akhlaq A. Farooqui, Aging: An important factor for the pathogenesis of neurodegenerative diseases Mechanisms of Ageing and Development. ,vol. 130, pp. 203- 215 ,(2009) , 10.1016/J.MAD.2008.11.006
Marcelo M Nociari, Assaf Shalev, Petros Benias, Carlo Russo, A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity Journal of Immunological Methods. ,vol. 213, pp. 157- 167 ,(1998) , 10.1016/S0022-1759(98)00028-3