作者: Asmaa A Zidan , Mohammed Al-Hawwas , Griffith B Perkins , Ghada M Mourad , Catherine JM Stapledon
DOI: 10.3390/IJMS22010459
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摘要: Elucidation of the biological functions extracellular vesicles (EVs) and their potential roles in physiological pathological processes is an expanding field research. In this study, we characterized USC-derived EVs studied capacity to modulate human immune response vitro. We found that are a heterogeneous population, ranging size from micro-vesicles (150 nm-1 μm) down exosomes (60-150 nm). Regarding immunomodulatory functions, upon isolation, nm) induced B cell proliferation IgM antibody secretion. Analysis EV contents unexpectedly revealed presence BAFF, APRIL, IL-6, CD40L, all known play central role stimulation, differentiation, humoral immunity. regard effect on T they resembled function mesenchymal stem (MSC)-derived previously described, suppressing activation. The finding transport potent bioactive cargo opens door novel therapeutic avenue for boosting responses immunodeficiency or cancer.