40 Hz auditory steady-state response in schizophrenia: Sensitivity to stimulation type (clicks versus flutter amplitude-modulated tones)

作者: Inga Griskova-Bulanova , Kastytis Dapsys , Sigita Melynyte , Aleksandras Voicikas , Valentinas Maciulis

DOI: 10.1016/J.NEULET.2017.10.025

关键词:

摘要: Auditory steady-state response (ASSR) at 40Hz has been proposed as a potential biomarker for schizophrenia. The ASSR studies in patients have used click stimulation or amplitude-modulated tones. However, the sensitivity of ASSRs to different types same group not previously evaluated. Two were tested this study: (1) clicks and (2) flutter-amplitude modulated mean phase-locking index, evoked amplitude event-related spectral perturbation values compared between schizophrenia (n=26) healthy controls (n=20). Both resulted observation impaired power measures late (200-500ms) controls. early-latency (0-100ms) part was diminished only. late-latency parameters obtained through correlated subjects but patients. We conclude that flutter tone stimulation, due its reveal entrainment deficits, is suitable use clinical populations. Careful consideration experimental settings can contribute interpretation deficits utilization biomarker.

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