Inter-hemispheric competition of sub-cortical structures is a crucial mechanism in paradoxical lesion effects and spatial neglect.

摘要: Publisher Summary The results show that the frequently perplexing and counter-intuitive patterns of intact, lesioned, paradoxically restored orienting behavior can be explained quite comprehensively by a simple mathematical model based on aspects real connectivity. connectivity structure employed in model, dynamic exhibits, make it clear competition among brain structures is an important mechanism for spatial attention cat potentially also humans. demonstrates paradoxical lesion effects, which present surprising set phenomena, need no means mysterious. Paradoxical restoration easily understood from across midline bilateral structures. Normal function arises balanced competition, attentional after primary lesions achieved redressing level such system efficiently influenced external visual input. However, cat, experimental behavioral effects lesions, connectional neuroanatomy, suggest principal subcortical one, particularly involving superior colliculi basal ganglia. These sub-cortical mechanisms are informed cortical processes representations (as spatially dependent model), but appears nonetheless to direct mutual inhibition midline,