Fueling Platelets

摘要: There has long been interest in the metabolic pathways occurring platelets and their relationship to function. Despite reliance on crude analytic tools inhibitors, early studies showed that must produce ATP maintain functionality.1 Platelet activation leads a significant increase glucose uptake, glycolysis, lactate production,2–5 suggesting that, addition oxidative phosphorylation, glycolysis is producer of fuel platelet Electron microscopy clearly show contain glycogen granules, which could serve as reservoir for energy production. Glucose can also be imported from outside through 3 classes facilitative transporters (glucose [GLUTs], sodium GLUTs, sugars will eventually exported transporters).6,7 These proteins facilitate transmembrane movement down concentration gradient either or sodium.6 Platelets at least 2 members GLUT family uniporters, GLUT1 GLUT3.8,9 Although may account basal uptake resting cells, GLUT3 drawn attention because it mobilized α-granules plasma membrane (Figure 1).4,5 In this issue, Fidler et al9 used platelet-specific knockout probe its role and, thus, roles regulated function. Figure 1. Mobilization (GLUT3) activated platelets. resides (PM), present mainly PM activation. There, promotes …