Prognostic Value of Survivin in Patients with Gastric Cancer: A Systematic Review with Meta-Analysis

摘要: Objective The prognostic significance of survivin for the survival patients with gastric cancer remains controversial. Thus, objective this study was to conduct a systematic review literature evaluating expression in as indicator. Methods Relevant searched using PubMed, EMBASE, and Chinese biomedicine databases. A meta-analysis association between overall performed. Studies were pooled summary hazard ratios (HRs) calculated. Subgroup analyses also conducted. Results Final analysis 1365 from 16 eligible studies Combined HR suggested that had an unfavorable impact on (HR=1.39, 95% CI: 1.16-1.68). The appeared significant when stratified according categorized by patients’ ethnicity, detection methods, type sample, estimate. combined English showed inverse effect (HR=1.40, 1.13-1.75), while non-English did not (HR=1.38, 0.93-2.05). When location expression, cytoplasm significantly associated poor prognosis (HR=1.46, 1.12-1.90). While nucleus (HR=1.29, 0.72-2.31), heterogeneity highly (chi-squared=11.5, I2=74%, p=0.009). Conclusions This cancer. Cytoplasmic may be regarded factor patients. In contrast, have survival.