Cerebral Angiogenesis and Expression of Angiogenic Factors in Aging Rats after Exercise

摘要: The effect that exercise has on angiogenesis in the aging rat is unknown. We initiated this study with intent to determine if could induce rats, as well adult rats reported previously. markers we used our endpoint were vascular endothelial growth factor (VEGF) and angiopoietin 1 2, density. Aged (22 month old) female Fisher 344 (n=16) exercised a treadmill 30 minutes each day for 3 weeks, or housed non-exercised controls same duration. At end of protocol, significant (p < 0.01) increase density microvessels was found within cerebral vasculature rats. Exercise also associated significantly increased mRNA expression 2 aged cohort A mild but four isoforms VEGF (120, 144, 164, 188) observed, VEGF120 VEGF144 being more markedly up-regulated than other two. protein increased. This demonstrates can be induced via exercise. overexpression angiogenic factors. These results support hypothesis an response chronic physical maintained aging.