Genetically modified heart valve xenografts
作者： John S. Logan , Guerard W. Byrne , Christopher G. A. Mcgregor , William R. Davies
DOI:
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摘要: The invention relates to heart valve xenografts from transgenic pigs having a disruption of an α1-3 galactosyl transferase nucleic acid sequence and use the for treating patient.
lens.org参考文章(62)
Alain F. Carpentier, Flexible heart valve leaflets ,(2000)
H Waldmann, S Meri, B P Morgan, M G Olavesen, R H Daniels, P J Lachmann, A Davies, Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers. Immunology. ,vol. 71, pp. 1- 9 ,(1990)
Sophie M. Carpentier, Alain F. Carpentier, Treatment of bioprosthetic tissues to mitigate post implantation calcification ,(2003)
C W van den Berg, B P Morgan, Complement-inhibiting activities of human CD59 and analogues from rat, sheep, and pig are not homologously restricted. Journal of Immunology. ,vol. 152, pp. 4095- 4101 ,(1994)
Stefan G. Schreck, Richard S. Rhee, William Recktenwald, Hung Ly Lam, Diana Nguyen-Thien-Nhon, Alain F. Carpentier, Flexible heart valve ,(2000)
Allan J. Robins, Martin J. Pearse, Robert J. Crawford, Anthony J. F. d'Apice, Pigs and pig cells having an inactivated α 1,3-galactosyl transferase gene ,(1997)
John B. Lowe, Peter L. Smith, Molecular cloning of a murine N-acetylgalactosamine transferase cDNA that determines expression of the T lymphocyte-specific CT oligosaccharide differentiation antigen. Journal of Biological Chemistry. ,vol. 269, pp. 15162- 15171 ,(1994) , 10.1016/S0021-9258(17)36587-0
Ian F. C. Mckenzie, Mauro S. Sandrin, USE OF PORCINE GAL $g(a)(1,3) GALACTOSYL TRANSFERASE IN XENOGRAFT THERAPIES ,(1994)
Kevin R. Stone, Xenograft heart valves ,(2004)
Herbert L. Heyneker, Rein Strijker, Paul J. A. Krimpenfort, Gerard Platenburg, Frank Pieper, Herman A. DeBoer, Sang H. Lee, Method of producing a transgenic bovine or transgenic bovine embryo ,(1993)