Anti-cancer effects of butyrate: use of micro-array technology to investigate mechanisms.

摘要: Epidemiological evidence suggests that a high intake of resistant starch and NSP protects against colo-rectal cancer. The mechanisms underlying this protection are thought to be mediated by the short-chain fatty acid butyrate, which is present in colonic lumen millimolar concentrations as result bacterial fermentation carbohydrates have resisted digestion small intestine. In vitro studies shown butyrate displays host chemo-preventative properties including increased apoptosis, reduced proliferation, down regulation angiogenesis, enhanced immunosurveillance anti-inflammatory effects cancer cell lines. However, molecular apparent actions largely unknown. supporting role an anti-cancer agent reviewed, with particular emphasis on those attempted elucidate mechanism action butyrate. Our understanding mechanistic its prevention likely advance considerably post-genomic era application genomic proteomic technologies. Studies described used gene array techniques investigate response cells These pioneering illustrate potential these technologies help characterise responses define (and other nutrients)