Apoptosis in Lung Injury and Disease

摘要: Pulmonary cell death may contribute significantly to acute and chronic lung injuries caused by various adverse environmental agents. cells die necrosis, apoptosis, other forms of regulated death. Apoptosis exerts a homeostatic function in defense development, through the removal dysfunctional regulating cellular proliferation. Lung apoptosis can occur as response oxidative stress, mechanical ventilation, ischemia/reperfusion, cigarette smoke exposure, injuries. The role pathogenesis disease remains controversial. act an adaptive process, removing cells, limiting inflammation damaged tissue, preventing On hand, excessive depletion critical populations, resulting loss function, emphysema, or undesirable proliferation, fibrosis pulmonary hypertension. An understanding cell-type-specific regulation facilitate development therapeutic strategies for treatment pathologies. This chapter reviews current evidence specific diseases, with emphasis on obstructive respiratory distress syndrome.